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Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates
Disulfide bonds provide a bioactivatable connection with applications in imaging and therapy. The circulation stability and intracellular release of disulfides are problematically coupled in that increasing stability causes a corresponding decrease in cleavage and payload release. However, an antibo...
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| Gepubliceerd in: | Chem Sci |
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| Hoofdauteurs: | , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Royal Society of Chemistry
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5365059/ https://ncbi.nlm.nih.gov/pubmed/28451181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc01831a |
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