Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Disulfide bonds provide a bioactivatable connection with applications in imaging and therapy. The circulation stability and intracellular release of disulfides are problematically coupled in that increasing stability causes a corresponding decrease in cleavage and payload release. However, an antibo...

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Bibliografische gegevens
Gepubliceerd in:Chem Sci
Hoofdauteurs: Pillow, Thomas H., Sadowsky, Jack D., Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R., Ha, Edward, Junutula, Jagath R., Flygare, John A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2017
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365059/
https://ncbi.nlm.nih.gov/pubmed/28451181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc01831a
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