Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M(1) receptors

BACKGROUND AND PURPOSE: We aimed to identify and develop novel, selective muscarinic M(1) receptor agonists as potential therapeutic agents for the symptomatic treatment of Alzheimer's disease. EXPERIMENTAL APPROACH: We developed and utilized a novel M(1) receptor occupancy assay to drive a str...

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Библиографические подробности
Опубликовано в: :Br J Pharmacol
Главные авторы: Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284335/
https://ncbi.nlm.nih.gov/pubmed/30276808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14510
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