Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M(1) receptors

BACKGROUND AND PURPOSE: We aimed to identify and develop novel, selective muscarinic M(1) receptor agonists as potential therapeutic agents for the symptomatic treatment of Alzheimer's disease. EXPERIMENTAL APPROACH: We developed and utilized a novel M(1) receptor occupancy assay to drive a str...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284335/
https://ncbi.nlm.nih.gov/pubmed/30276808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14510
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados