Characterization of a CNS penetrant, selective M(1) muscarinic receptor agonist, 77-LH-28-1

BACKGROUND AND PURPOSE: M(1) muscarinic ACh receptors (mAChRs) represent an attractive drug target for the treatment of cognitive deficits associated with diseases such as Alzheimer's disease and schizophrenia. However, the discovery of subtype-selective mAChR agonists has been hampered by the...

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Detalles Bibliográficos
Autores principales: Langmead, C J, Austin, N E, Branch, C L, Brown, J T, Buchanan, K A, Davies, C H, Forbes, I T, Fry, V A H, Hagan, J J, Herdon, H J, Jones, G A, Jeggo, R, Kew, J N C, Mazzali, A, Melarange, R, Patel, N, Pardoe, J, Randall, A D, Roberts, C, Roopun, A, Starr, K R, Teriakidis, A, Wood, M D, Whittington, M, Wu, Z, Watson, J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2008
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2451039/
https://ncbi.nlm.nih.gov/pubmed/18454168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.152
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