Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M(1) receptors

BACKGROUND AND PURPOSE: We aimed to identify and develop novel, selective muscarinic M(1) receptor agonists as potential therapeutic agents for the symptomatic treatment of Alzheimer's disease. EXPERIMENTAL APPROACH: We developed and utilized a novel M(1) receptor occupancy assay to drive a str...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284335/
https://ncbi.nlm.nih.gov/pubmed/30276808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14510
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