Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M(1) receptors

BACKGROUND AND PURPOSE: We aimed to identify and develop novel, selective muscarinic M(1) receptor agonists as potential therapeutic agents for the symptomatic treatment of Alzheimer's disease. EXPERIMENTAL APPROACH: We developed and utilized a novel M(1) receptor occupancy assay to drive a str...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284335/
https://ncbi.nlm.nih.gov/pubmed/30276808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14510
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