Synergistic cross‐talk of hedgehog and interleukin‐6 signaling drives growth of basal cell carcinoma

Persistent activation of hedgehog (HH)/GLI signaling accounts for the development of basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer with rising incidence. Targeting HH/GLI signaling by approved pathway inhibitors can provide significant therapeutic benefit to BCC patients. Howev...

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Veröffentlicht in:Int J Cancer
Hauptverfasser: Sternberg, Christina, Gruber, Wolfgang, Eberl, Markus, Tesanovic, Suzana, Stadler, Manuela, Elmer, Dominik P., Schlederer, Michaela, Grund, Sandra, Roos, Simone, Wolff, Florian, Kaur, Supreet, Mangelberger, Doris, Lehrach, Hans, Hache, Hendrik, Wierling, Christoph, Laimer, Josef, Lackner, Peter, Wiederstein, Markus, Kasper, Maria, Risch, Angela, Petzelbauer, Peter, Moriggl, Richard, Kenner, Lukas, Aberger, Fritz
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2018
Schlagworte:
Molecular Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282712/
https://ncbi.nlm.nih.gov/pubmed/29987839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31724
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