Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene specificity, and oncogenic activity of HH signaling depend profoundly on interactions with other pathways, such as epidermal growth factor receptor-me...

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Bibliografische gegevens
Hoofdauteurs: Götschel, Frank, Berg, Daniela, Gruber, Wolfgang, Bender, Christian, Eberl, Markus, Friedel, Myriam, Sonntag, Johanna, Rüngeler, Elena, Hache, Hendrik, Wierling, Christoph, Nietfeld, Wilfried, Lehrach, Hans, Frischauf, Annemarie, Schwartz-Albiez, Reinhard, Aberger, Fritz, Korf, Ulrike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677915/
https://ncbi.nlm.nih.gov/pubmed/23762360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065403
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