Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene specificity, and oncogenic activity of HH signaling depend profoundly on interactions with other pathways, such as epidermal growth factor receptor-me...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Götschel, Frank, Berg, Daniela, Gruber, Wolfgang, Bender, Christian, Eberl, Markus, Friedel, Myriam, Sonntag, Johanna, Rüngeler, Elena, Hache, Hendrik, Wierling, Christoph, Nietfeld, Wilfried, Lehrach, Hans, Frischauf, Annemarie, Schwartz-Albiez, Reinhard, Aberger, Fritz, Korf, Ulrike
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2013
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677915/
https://ncbi.nlm.nih.gov/pubmed/23762360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065403
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