Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene specificity, and oncogenic activity of HH signaling depend profoundly on interactions with other pathways, such as epidermal growth factor receptor-me...

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Détails bibliographiques
Auteurs principaux: Götschel, Frank, Berg, Daniela, Gruber, Wolfgang, Bender, Christian, Eberl, Markus, Friedel, Myriam, Sonntag, Johanna, Rüngeler, Elena, Hache, Hendrik, Wierling, Christoph, Nietfeld, Wilfried, Lehrach, Hans, Frischauf, Annemarie, Schwartz-Albiez, Reinhard, Aberger, Fritz, Korf, Ulrike
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677915/
https://ncbi.nlm.nih.gov/pubmed/23762360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065403
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