Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene specificity, and oncogenic activity of HH signaling depend profoundly on interactions with other pathways, such as epidermal growth factor receptor-me...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Götschel, Frank, Berg, Daniela, Gruber, Wolfgang, Bender, Christian, Eberl, Markus, Friedel, Myriam, Sonntag, Johanna, Rüngeler, Elena, Hache, Hendrik, Wierling, Christoph, Nietfeld, Wilfried, Lehrach, Hans, Frischauf, Annemarie, Schwartz-Albiez, Reinhard, Aberger, Fritz, Korf, Ulrike
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677915/
https://ncbi.nlm.nih.gov/pubmed/23762360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065403
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