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Olanzapine metabolism and the significance of the UGT1A4(48V) and UGT2B10(67Y) variants

Olanzapine (OLZ) is an antipsychotic used in the treatment of schizophrenia, bipolar disorder, and treatment-resistant depression. Glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes is the major mode of OLZ metabolism and polymorphisms in these enzymes could contribute to in...

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Bibliografiske detaljer
Udgivet i:Pharmacogenet Genomics
Main Authors: Erickson, Kathryn K., Zhu, Junjia, Lazarus, Philip
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281394/
https://ncbi.nlm.nih.gov/pubmed/21750471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328348c76b
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