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Glucuronidation of the second-generation antipsychotic clozapine and its active metabolite N-desmethylclozapine. Potential importance of the UGT1A1 A(TA)(7)TAA and UGT1A4 L48V polymorphisms.
INTRODUCTION: Clozapine (CLZ) is a second-generation antipsychotic FDA-approved for refractory schizophrenia, and glucuronidation is an important pathway in its metabolism. The goal of this study was to fully characterize the CLZ glucuronidation pathway and examine whether polymorphisms in active gl...
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| Publicado no: | Pharmacogenet Genomics |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6278935/ https://ncbi.nlm.nih.gov/pubmed/22565219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328354026b |
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