Glucuronidation genotypes and nicotine metabolic phenotypes: Importance of UGT2B10 and UGT2B17 knock-out polymorphisms

Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ~22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UGTs 2B10 and 2B17 play major roles in nicotine glucuronidati...

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Bibliographic Details
Main Authors: Chen, Gang, Giambrone, Nino E., Dluzen, Douglas F., Muscat, Joshua E., Berg, Arthur, Gallagher, Carla J., Lazarus, Philip
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998997/
https://ncbi.nlm.nih.gov/pubmed/20876810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4582
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