UGT2B10 genotype influences nicotine glucuronidation, oxidation and consumption

BACKGROUND: Tobacco exposure is routinely assessed by quantifying nicotine metabolites in plasma or urine. On average, 80% of nicotine undergoes C-oxidation to cotinine. However, interindividual variation in nicotine glucuronidation is substantial and glucuronidation accounts for from 0 to 40% of to...

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Главные авторы: Berg, Jeannette Zinggeler, von Weymarn, Linda, Thompson, Elizabeth A., Wickham, Katherine M., Weisensel, Natalie A., Hatsukami, Dorothy K., Murphy, Sharon E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882998/
https://ncbi.nlm.nih.gov/pubmed/20501767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-09-0959
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