N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice

Immune responses to factor VIII remain the greatest complication in the treatment of severe hemophilia A. Recent epidemiological evidence has highlighted that recombinant factor VIII produced in baby hamster kidney cells is more immunogenic than factor VIII produced in Chinese hamster ovary cells. G...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Lai, Jesse D., Swystun, Laura L., Cartier, Dominique, Nesbitt, Kate, Zhang, Cunjie, Hough, Christine, Dennis, James W., Lillicrap, David
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278987/
https://ncbi.nlm.nih.gov/pubmed/30002126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.188219
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