Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms

The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avoidance of factor VIII exposure during innate immun...

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Publicado no:Haematologica
Main Authors: Georgescu, Maria T., Moorehead, Paul C., van Velzen, Alice S., Nesbitt, Kate, Reipert, Birgit M., Steinitz, Katharina N., Schuster, Maria, Hough, Christine, Lillicrap, David
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068046/
https://ncbi.nlm.nih.gov/pubmed/29674503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.189852
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