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Influence of Aggregation on Immunogenicity of Recombinant Human Factor VIII in Hemophilia A Mice
Recombinant human factor VIII (rFVIII), a multidomain glycoprotein is used in replacement therapy for treatment of hemophilia A. Unfortunately, 15%–30% of the treated patients develop inhibitory antibodies. The pathogenesis of antibody development is not completely understood. The presence of aggreg...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574426/ https://ncbi.nlm.nih.gov/pubmed/16372314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.20529 |
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