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Aggregation Kinetics of Recombinant Human FVIII (rFVIII)

The physical phenomenon of aggregation can have profound impact on the stability of therapeutic proteins. This study focuses on the aggregation behavior of recombinant human FVIII (rFVIII), a multi-domain protein used as the first line of therapy for hemophilia A, a bleeding disorder caused by the d...

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Autors principals: RAMANI, KARTHIK, PUROHIT, VIVEK, MIDDAUGH, C. RUSSELL, BALASUBRAMANIAN, SATHYAMANGALAM V.
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574007/
https://ncbi.nlm.nih.gov/pubmed/16052549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.20432
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