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Phosphatidylserine Containing Liposomes Reduce Immunogenicity of Recombinant Human Factor VIII (rFVIII) in a Murine Model of Hemophilia A

Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder. Replacement therapy using recombinant human FVIII (rFVIII) is the main therapy. However, approximately 15-30% of patients develop inhibitory antibodies that neutralize rFVIII act...

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Detalhes bibliográficos
Main Authors: RAMANI, KARTHIK, MICLEA, RAZVAN D., PUROHIT, VIVEK S., MAGER, DONALD E., STRAUBINGER, ROBERT M., BALU-IYER, SATHY V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574438/
https://ncbi.nlm.nih.gov/pubmed/17705286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21102
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