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Effect of route of administration of human recombinant Factor VIII on its immunogenicity in Hemophilia A mice

Factor VIII is a multi-domain glycoprotein and is an essential cofactor in the blood coagulation cascade. Its deficiency or dysfunction causes Hemophilia A, a bleeding disorder. Replacement using exogenous recombinant Factor VIII (FVIII) is the first line of therapy for Hemophilia A. Immunogenicity,...

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Bibliografske podrobnosti
Main Authors: Peng, Aaron, Gaitonde, Puneet, Kosloski, Matthew P., Miclea, Razvan D., Varma, Prashant, Balu-Iyer, Sathy V.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796435/
https://ncbi.nlm.nih.gov/pubmed/19499565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21765
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