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Effect of route of administration of human recombinant Factor VIII on its immunogenicity in Hemophilia A mice
Factor VIII is a multi-domain glycoprotein and is an essential cofactor in the blood coagulation cascade. Its deficiency or dysfunction causes Hemophilia A, a bleeding disorder. Replacement using exogenous recombinant Factor VIII (FVIII) is the first line of therapy for Hemophilia A. Immunogenicity,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796435/ https://ncbi.nlm.nih.gov/pubmed/19499565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21765 |
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