PEGylation of a Factor VIII–Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice

Hemophilia A is an X-linked bleeding disorder caused by the deficiency of factor VIII (FVIII). Exogenous FVIII is administered therapeutically, and due to a short half-life, frequent infusions are often required. Fifteen to thirty-five percent of severe hemophilia A patients develop inhibitory antib...

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Bibliographic Details
Main Authors: Peng, Aaron, Kosloski, Matthew P., Nakamura, Genki, Ding, Hong, Balu-Iyer, Sathy V.
Format: Artigo
Language:Inglês
Published: Springer US 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291190/
https://ncbi.nlm.nih.gov/pubmed/22173945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9309-2
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