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Nonlinear pharmacokinetics of Factor VIII and its phosphatidylinositol lipidic complex in hemophilia A mice
Factor VIII (FVIII) is an important cofactor in the blood coagulation cascade and its deficiency or dysfunction causes Hemophilia A (HA), a bleeding disorder. Replacement with recombinant FVIII is limited by a short half-life and the development of inhibitory antibodies. We have developed a phosphat...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976741/ https://ncbi.nlm.nih.gov/pubmed/24259187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.1880 |
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