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Nonlinear pharmacokinetics of Factor VIII and its phosphatidylinositol lipidic complex in hemophilia A mice

Factor VIII (FVIII) is an important cofactor in the blood coagulation cascade and its deficiency or dysfunction causes Hemophilia A (HA), a bleeding disorder. Replacement with recombinant FVIII is limited by a short half-life and the development of inhibitory antibodies. We have developed a phosphat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kosloski, Matthew P., Pisal, Dipak S., Mager, Donald E., Balu-Iyer, Sathy V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976741/
https://ncbi.nlm.nih.gov/pubmed/24259187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.1880
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