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Allometry of Factor VIII and informed scaling of next generation therapeutic proteins
Allometric scaling has been applied to the pharmacokinetics (PK) of factor VIII (FVIII), but published relationships are based on relatively small subsets of available data. Numerous next generation forms of FVIII are being developed (e.g. Fc fusion, PEGylated, and liposomal formulations) and tradit...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3676521/ https://ncbi.nlm.nih.gov/pubmed/23620343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23566 |
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