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Allometry of Factor VIII and informed scaling of next generation therapeutic proteins

Allometric scaling has been applied to the pharmacokinetics (PK) of factor VIII (FVIII), but published relationships are based on relatively small subsets of available data. Numerous next generation forms of FVIII are being developed (e.g. Fc fusion, PEGylated, and liposomal formulations) and tradit...

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Autors principals: Kosloski, Matthew P., Pisal, Dipak S., Mager, Donald E., Balu-Iyer, Sathy V.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676521/
https://ncbi.nlm.nih.gov/pubmed/23620343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23566
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