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Allometry of Factor VIII and informed scaling of next generation therapeutic proteins

Allometric scaling has been applied to the pharmacokinetics (PK) of factor VIII (FVIII), but published relationships are based on relatively small subsets of available data. Numerous next generation forms of FVIII are being developed (e.g. Fc fusion, PEGylated, and liposomal formulations) and tradit...

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Detaylı Bibliyografya
Asıl Yazarlar: Kosloski, Matthew P., Pisal, Dipak S., Mager, Donald E., Balu-Iyer, Sathy V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676521/
https://ncbi.nlm.nih.gov/pubmed/23620343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23566
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