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Methods for Improving Aptamer Binding Affinity

Aptamers are single stranded oligonucleotides that bind a wide range of biological targets. Although aptamers can be isolated from pools of random sequence oligonucleotides using affinity-based selection, aptamers with high affinities are not always obtained. Therefore, further refinement of aptamer...

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Publicado en:Molecules
Main Authors: Hasegawa, Hijiri, Savory, Nasa, Abe, Koichi, Ikebukuro, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273865/
https://ncbi.nlm.nih.gov/pubmed/27043498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21040421
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