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Improvement of Aptamer Affinity by Dimerization

To increase the affinities of aptamers for their targets, we designed an aptamer dimer for thrombin and VEGF. This design is based on the avidity of the antibody, which enables the aptamer to connect easily since it is a single-strand nucleic acid. In this study, we connected a 15-mer thrombin-bindi...

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Hlavní autoři: Hasegawa, Hijiri, Taira, Ken-ichi, Sode, Koji, Ikebukuro, Kazunori
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Diversity Preservation International (MDPI) 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927496/
https://ncbi.nlm.nih.gov/pubmed/27879754
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