BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia

The fusion oncoprotein BCR-ABL1 exhibits aberrant tyrosine kinase activity and it has been proposed that it deregulates signaling networks involving both transcription factors and non-coding microRNAs that result in chronic myeloid leukemia (CML). Previously, microRNA expression profiling showed der...

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Udgivet i:Haematologica
Main Authors: Srutova, Klara, Curik, Nikola, Burda, Pavel, Savvulidi, Filipp, Silvestri, Giovannino, Trotta, Rossana, Klamova, Hana, Pecherkova, Pavla, Sovova, Zofie, Koblihova, Jitka, Stopka, Tomas, Perrotti, Danilo, Polakova, Katerina Machova
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269310/
https://ncbi.nlm.nih.gov/pubmed/30049824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.193086
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