Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation

The aging-associated increase of cancer risk is linked with stromal fibroblast senescence and concomitant cancer-associated fibroblast (CAF) activation. Surprisingly little is known about the role of androgen receptor (AR) signaling in this context. We have found downmodulated AR expression in derma...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Clocchiatti, Andrea, Ghosh, Soumitra, Procopio, Maria-Giuseppina, Mazzeo, Luigi, Bordignon, Pino, Ostano, Paola, Goruppi, Sandro, Bottoni, Giulia, Katarkar, Atul, Levesque, Mitchell, Kölblinger, Peter, Dummer, Reinhard, Neel, Victor, Özdemir, Berna C., Dotto, G. Paolo
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264730/
https://ncbi.nlm.nih.gov/pubmed/30395538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99159
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