Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation

Cancer-associated fibroblasts (CAFs) are important for tumor initiation and promotion. CSL, a transcriptional repressor and Notch mediator, suppresses CAF activation. Like CSL, ATF3, a stress-responsive transcriptional repressor, is down-modulated in skin cancer stromal cells, and Atf3 knockout mice...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kim, Dong Eun, Procopio, Maria-Giuseppina, Ghosh, Soumitra, Jo, Seung-Hee, Goruppi, Sandro, Magliozzi, Francesco, Bordignon, Pino, Neel, Victor, Angelino, Paolo, Dotto, G. Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551580/
https://ncbi.nlm.nih.gov/pubmed/28684431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170724
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