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Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism

Cancer-associated fibroblasts (CAFs) are important at all tumor stages. CSL/RBPJκ suppresses the gene expression program leading to CAF activation and associated metabolic reprogramming, as well as autophagy. Little is known about CSL protein turnover, especially in the tumor microenvironment. We re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Rep
Hauptverfasser: Goruppi, Sandro, Jo, Seung-Hee, Laszlo, Csaba, Clocchiatti, Andrea, Neel, Victor, Dotto, G. Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200139/
https://ncbi.nlm.nih.gov/pubmed/30231994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.043
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