NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment. Genomic alterations in these cells remain a point of contention. We report that CAFs from skin squamous cell carcinomas (SCCs) display chromosomal alterations, with heterogeneous NOTCH1 gene amplification and ove...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Katarkar, Atul, Bottoni, Giulia, Clocchiatti, Andrea, Goruppi, Sandro, Bordignon, Pino, Lazzaroni, Francesca, Gregnanin, Ilaria, Ostano, Paola, Neel, Victor, Dotto, G. Paolo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550609/
https://ncbi.nlm.nih.gov/pubmed/33046701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18919-2
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