Epigenetic modification enhances the cytotoxicity of busulfan and 4-hydroperoxycyclophosphamide in AML cells

The combination of DNA alkylating agents busulfan (Bu) and cyclophosphamide is the most commonly used myeloablative pre-transplant conditioning therapy for myeloid leukemias. However, it is associated with significant non-relapse mortality, which prohibits dose-escalation to control relapse. We hypo...

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Bibliografske podrobnosti
izdano v:Exp Hematol
Main Authors: Valdez, Benigno C., Tang, Xiaowen, Li, Yang, Murray, David, Liu, Yan, Popat, Uday, Champlin, Richard E., Andersson, Borje S.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262883/
https://ncbi.nlm.nih.gov/pubmed/30102945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.08.002
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