Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells

Novel approaches to pre-transplant conditioning are needed to improve treatment of advanced T-cell malignancies. We investigated the synergism of fludarabine (Flu), clofarabine (Clo), busulfan (Bu), and romidepsin (Rom) in T-cell lines and patient-derived cell samples. [Flu+Clo+Bu+Rom] had combinati...

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Detalhes bibliográficos
Publicado no:Leuk Res
Main Authors: Valdez, Benigno C., Brammer, Jonathan E., Li, Yang, Murray, David, Teo, Esmeralda C., Liu, Yan, Hosing, Chitra, Nieto, Yago, Champlin, Richard E., Andersson, Borje S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961533/
https://ncbi.nlm.nih.gov/pubmed/27294334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2016.05.019
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