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The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells

The combination of gemcitabine (Gem), busulfan (Bu) and melphalan (Mel) is a promising regimen for autologous stem-cell transplantation (SCT) for lymphomas. To further improve the efficacy of [Gem+Bu+Mel], we added PARP inhibitor olaparib (Ola). We hypothesized that Ola would inhibit the repair of d...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Leuk Lymphoma
Main Authors: Valdez, Benigno C., Li, Yang, Murray, David, Liu, Yan, Nieto, Yago, Champlin, Richard E., Andersson, Borje S.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526721/
https://ncbi.nlm.nih.gov/pubmed/28394191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2017.1306647
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