1346. The Tetrazole VT-1598 Is Efficacious in a Murine Model of Invasive Aspergillosis with a PK/PD Expected of a Mold-Active CYP51 Inhibitor

BACKGROUND: VT-1598 is a novel fungal CYP51 inhibitor with potent in vitro activity against yeast, mold, and endemic pathogenic fungi (Wiederhold, JAC, 2017). Its tetrazole-based rational drug design imparts much greater selectivity vs. human CYPs (Yates, BMCL, 2017), which could reduce human CYP-re...

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Published in:Open Forum Infect Dis
Main Authors: Garvey, Edward P, Sharp, Andrew, Warn, Peter, Yates, Christopher M, Schotzinger, Robert J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254293/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1177
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