Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease

Tau is the major constituent of neurofibrillary tangles in Alzheimer’s disease (AD), but the mechanism underlying tau-associated neural damage remains unclear. Here we show that tau can directly interact with nucleoporins of the nuclear pore complex (NPC) and affect their structural and functional i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuron
Hauptverfasser: Eftekharzadeh, Bahareh, Daigle, J. Gavin, Kapinos, Larisa E., Coyne, Alyssa, Schiantarelli, Julia, Carlomagno, Yari, Cook, Casey, Miller, Sean J., Dujardin, Simon, Amaral, Ana S., Grima, Jonathan C., Bennett, Rachel E., Tepper, Katharina, DeTure, Michael, Vanderburgh, Charles R., Corjuc, Bianca T., DeVos, Sarah L., Gonzalez, Jose Antonio, Chew, Jeannie, Vidensky, Svetlana, Gage, Fred H., Mertens, Jerome, Troncoso, Juan, Mandelkow, Eckhard, Salvatella, Xavier, Lim, Roderick Y. H., Petrucelli, Leonard, Wegmann, Susanne, Rothstein, Jeffrey D., Hyman, Bradley T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240334/
https://ncbi.nlm.nih.gov/pubmed/30189209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.07.039
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge