Stress granule assembly disrupts nucleocytoplasmic transport

Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common genetic cause of ALS/FTD. Furthermore, nucleocytoplasmic tra...

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Pubblicato in:Cell
Autori principali: Zhang, Ke, Daigle, J. Gavin, Cunningham, Kathleen M., Coyne, Alyssa N., Ruan, Kai, Grima, Jonathan C., Bowen, Kelly E., Wadhwa, Harsh, Yang, Peiguo, Rigo, Frank, Taylor, J. Paul, Gitler, Aaron D., Rothstein, Jeffrey D., Lloyd, Thomas E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083872/
https://ncbi.nlm.nih.gov/pubmed/29628143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.025
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