Stress granule assembly disrupts nucleocytoplasmic transport

Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common genetic cause of ALS/FTD. Furthermore, nucleocytoplasmic tra...

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Библиографические подробности
Опубликовано в: :Cell
Главные авторы: Zhang, Ke, Daigle, J. Gavin, Cunningham, Kathleen M., Coyne, Alyssa N., Ruan, Kai, Grima, Jonathan C., Bowen, Kelly E., Wadhwa, Harsh, Yang, Peiguo, Rigo, Frank, Taylor, J. Paul, Gitler, Aaron D., Rothstein, Jeffrey D., Lloyd, Thomas E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083872/
https://ncbi.nlm.nih.gov/pubmed/29628143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.025
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