Stress granule assembly disrupts nucleocytoplasmic transport

Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common genetic cause of ALS/FTD. Furthermore, nucleocytoplasmic tra...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Zhang, Ke, Daigle, J. Gavin, Cunningham, Kathleen M., Coyne, Alyssa N., Ruan, Kai, Grima, Jonathan C., Bowen, Kelly E., Wadhwa, Harsh, Yang, Peiguo, Rigo, Frank, Taylor, J. Paul, Gitler, Aaron D., Rothstein, Jeffrey D., Lloyd, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083872/
https://ncbi.nlm.nih.gov/pubmed/29628143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.025
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