The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors

BACKGROUND: Dolutegravir (DTG) is an integrase strand-transfer inhibitor (INSTI) used for treatment of human immunodeficiency virus (HIV)–infected individuals. Owing to its high genetic barrier to resistance, DTG has been clinically investigated as maintenance monotherapy to maintain viral suppressi...

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Vydáno v:J Infect Dis
Hlavní autoři: Pham, Hanh T, Labrie, Lydia, Wijting, Ingeborg E A, Hassounah, Said, Lok, Ka Yee, Portna, Inna, Goring, Mark E, Han, Yingshan, Lungu, Cynthia, van der Ende, Marchina E, Brenner, Bluma G, Boucher, Charles A, Rijnders, Bart J A, van Kampen, Jeroen J A, Mesplède, Thibault, Wainberg, Mark A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240331/
https://ncbi.nlm.nih.gov/pubmed/29617824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy175
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