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HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity

Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretrovirals to be approved for the treatment of HIV infection. Canonical resistance to these competitive inhibitors develops through substitutions in the integrase active site that disrupt drug-protein interactions. However, r...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Anstett, Kaitlin, Brenner, Bluma, Mesplède, Thibault, Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640858/
https://ncbi.nlm.nih.gov/pubmed/28835492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00912-17
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