The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors

BACKGROUND: Dolutegravir (DTG) is an integrase strand-transfer inhibitor (INSTI) used for treatment of human immunodeficiency virus (HIV)–infected individuals. Owing to its high genetic barrier to resistance, DTG has been clinically investigated as maintenance monotherapy to maintain viral suppressi...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Pham, Hanh T, Labrie, Lydia, Wijting, Ingeborg E A, Hassounah, Said, Lok, Ka Yee, Portna, Inna, Goring, Mark E, Han, Yingshan, Lungu, Cynthia, van der Ende, Marchina E, Brenner, Bluma G, Boucher, Charles A, Rijnders, Bart J A, van Kampen, Jeroen J A, Mesplède, Thibault, Wainberg, Mark A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240331/
https://ncbi.nlm.nih.gov/pubmed/29617824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy175
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