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Role of EphB3 receptor in mediating head and neck tumor growth, cell migration, and response to PI3K inhibitor

Eph proteins have emerged as critical drivers affecting tumor growth and progression in human malignancies. Our TCGA data analysis showed that EphB3, a receptor tyrosine kinase, is frequently co-amplified with PIK3CA in head and neck squamous cell carcinoma (HNSCC). We therefore hypothesized that Ep...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer Ther
Autori principali: Bhatia, Shilpa, Griego, Anastacia, Lennon, Shelby, Oweida, Ayman, Sharma, Jaspreet, Rohmer, Christina, Uyanga, Nomin, Bukkapatnam, Sanjana, Court, Benjamin Van, Raben, David, Young, Christian, Heasley, Lynn, Karam, Sana D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238629/
https://ncbi.nlm.nih.gov/pubmed/29970482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1163
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