Role of EphB3 receptor in mediating head and neck tumor growth, cell migration, and response to PI3K inhibitor

Eph proteins have emerged as critical drivers affecting tumor growth and progression in human malignancies. Our TCGA data analysis showed that EphB3, a receptor tyrosine kinase, is frequently co-amplified with PIK3CA in head and neck squamous cell carcinoma (HNSCC). We therefore hypothesized that Ep...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Bhatia, Shilpa, Griego, Anastacia, Lennon, Shelby, Oweida, Ayman, Sharma, Jaspreet, Rohmer, Christina, Uyanga, Nomin, Bukkapatnam, Sanjana, Court, Benjamin Van, Raben, David, Young, Christian, Heasley, Lynn, Karam, Sana D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238629/
https://ncbi.nlm.nih.gov/pubmed/29970482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1163
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