Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration

PURPOSE: Radiotherapy (RT) can transform the immune landscape and render poorly immunogenic tumors sensitive to PD-L1 inhibition. Here, we established that the response to combined RT and PD-L1 inhibition is transient and investigated mechanisms of resistance. EXPERIMENTAL DESIGN: Mechanisms of resi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Oweida, Ayman, Hararah, Mohammad K., Phan, Andy, Binder, David, Bhatia, Shilpa, Lennon, Shelby, Bukkapatnam, Sanjana, Van Court, Benjamin, Uyanga, Nomin, Darragh, Laurel, Min Kim, Hyun, Raben, David, Tan, Aik Choon, Heasley, Lynn, Clambey, Eric, Nemenoff, Raphael, Karam, Sana D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886391/
https://ncbi.nlm.nih.gov/pubmed/30042205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1038
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi