Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma

Immunotherapy clinical trials targeting the programmed-death ligand axis (PD-1/PD-L1) show that most head and neck squamous cell carcinoma (HNSCC) patients are resistant to PD-1/PD-L1 inhibition. We investigated whether local radiation to the tumor can transform the immune landscape and render poorl...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Oweida, Ayman, Lennon, Shelby, Calame, Dylan, Korpela, Sean, Bhatia, Shilpa, Sharma, Jaspreet, Graham, Caleb, Binder, David, Serkova, Natalie, Raben, David, Heasley, Lynn, Clambey, Eric, Nemenoff, Raphael, Karam, Sana D.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665079/
https://ncbi.nlm.nih.gov/pubmed/29123967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1356153
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