Inhibition of EphB4–Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers

PURPOSE: The clinical success of targeted therapies such as cetuximab and radiotherapy (RT) is hampered by the low response rates and development of therapeutic resistance. In the current study, we investigated the involvement of EphB4–ephrin-B2 protumorigenic signaling in mediating resistance to EG...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Bhatia, Shilpa, Sharma, Jaspreet, Bukkapatnam, Sanjana, Oweida, Ayman, Lennon, Shelby, Phan, Andy, Milner, Dallin, Uyanga, Nomin, Jimeno, Antonio, Raben, David, Somerset, Hilary, Heasley, Lynn, Karam, Sana D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886390/
https://ncbi.nlm.nih.gov/pubmed/29848571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0327
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