Pancreatic tumor microenvironment modulation by EphB4-ephrinB2 inhibition and radiation combination

PURPOSE: A driving factor in pancreatic ductal adenocarcinoma (PDAC) treatment resistance is the tumor microenvironment, which is highly immunosuppressive. One potent immunological adjuvant is radiation therapy. Radiation, however, has also been shown to induce immunosuppressive factors, which can c...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Lennon, Shelby, Oweida, Ayman, Milner, Dallin, Phan, Andy V., Bhatia, Shilpa, Van Court, Benjamin, Darragh, Laurel, Mueller, Adam C., Raben, David, Martínez-Torrecuadrada, Jorge L., Pitts, Todd M., Somerset, Hilary, Jordan, Kimberly R., Hansen, Kirk C., Williams, Jason, Messersmith, Wells A., Schulick, Richard D., Owens, Philip, Goodman, Karyn A., Karam, Sana D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548606/
https://ncbi.nlm.nih.gov/pubmed/30944125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2811
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