Pancreatic tumor microenvironment modulation by EphB4-ephrinB2 inhibition and radiation combination

PURPOSE: A driving factor in pancreatic ductal adenocarcinoma (PDAC) treatment resistance is the tumor microenvironment, which is highly immunosuppressive. One potent immunological adjuvant is radiation therapy. Radiation, however, has also been shown to induce immunosuppressive factors, which can c...

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發表在:Clin Cancer Res
Main Authors: Lennon, Shelby, Oweida, Ayman, Milner, Dallin, Phan, Andy V., Bhatia, Shilpa, Van Court, Benjamin, Darragh, Laurel, Mueller, Adam C., Raben, David, Martínez-Torrecuadrada, Jorge L., Pitts, Todd M., Somerset, Hilary, Jordan, Kimberly R., Hansen, Kirk C., Williams, Jason, Messersmith, Wells A., Schulick, Richard D., Owens, Philip, Goodman, Karyn A., Karam, Sana D.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548606/
https://ncbi.nlm.nih.gov/pubmed/30944125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2811
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