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Pancreatic tumor microenvironment modulation by EphB4-ephrinB2 inhibition and radiation combination

PURPOSE: A driving factor in pancreatic ductal adenocarcinoma (PDAC) treatment resistance is the tumor microenvironment, which is highly immunosuppressive. One potent immunological adjuvant is radiation therapy. Radiation, however, has also been shown to induce immunosuppressive factors, which can c...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Clin Cancer Res
المؤلفون الرئيسيون: Lennon, Shelby, Oweida, Ayman, Milner, Dallin, Phan, Andy V., Bhatia, Shilpa, Van Court, Benjamin, Darragh, Laurel, Mueller, Adam C., Raben, David, Martínez-Torrecuadrada, Jorge L., Pitts, Todd M., Somerset, Hilary, Jordan, Kimberly R., Hansen, Kirk C., Williams, Jason, Messersmith, Wells A., Schulick, Richard D., Owens, Philip, Goodman, Karyn A., Karam, Sana D.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2019
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548606/
https://ncbi.nlm.nih.gov/pubmed/30944125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2811
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