LIN28 selectively modulates a subclass of let-7 microRNAs

LIN28 is a bipartite RNA-binding protein that post-transcriptionally inhibits the biogenesis of let-7 microRNAs to regulate development and influence disease states. However, the mechanisms of let-7 suppression remains poorly understood, because LIN28 recognition depends on coordinated targeting by...

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Udgivet i:Mol Cell
Main Authors: Ustianenko, Dmytro, Chiu, Hua-Sheng, Treiber, Thomas, Weyn-Vanhentenryck, Sebastien M., Treiber, Nora, Meister, Gunter, Sumazin, Pavel, Zhang, Chaolin
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238216/
https://ncbi.nlm.nih.gov/pubmed/30029005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.029
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