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The Lin28 cold-shock domain remodels pre-let-7 microRNA

The RNA-binding protein Lin28 regulates the processing of a developmentally important group of microRNAs, the let-7 family. Lin28 blocks the biogenesis of let-7 in embryonic stem cells and thereby prevents differentiation. It was shown that both RNA-binding domains (RBDs) of this protein, the cold-s...

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Autores principales: Mayr, Florian, Schütz, Anja, Döge, Nadine, Heinemann, Udo
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424542/
https://ncbi.nlm.nih.gov/pubmed/22570413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks355
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