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The Lin28 cold-shock domain remodels pre-let-7 microRNA
The RNA-binding protein Lin28 regulates the processing of a developmentally important group of microRNAs, the let-7 family. Lin28 blocks the biogenesis of let-7 in embryonic stem cells and thereby prevents differentiation. It was shown that both RNA-binding domains (RBDs) of this protein, the cold-s...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3424542/ https://ncbi.nlm.nih.gov/pubmed/22570413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks355 |
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