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Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms
Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase (Zcchc11/TUTase4) to let-7 precursors to block processing by Dicer in the cell cytoplasm. Here we find that unlike Lin28A, Lin28B represses let-7 pr...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3227872/ https://ncbi.nlm.nih.gov/pubmed/22118463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.039 |
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