Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms

Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase (Zcchc11/TUTase4) to let-7 precursors to block processing by Dicer in the cell cytoplasm. Here we find that unlike Lin28A, Lin28B represses let-7 pr...

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Autori principali: Piskounova, Elena, Polytarchou, Christos, Thornton, James E., Hagan, John P., LaPierre, Robert J., Pothoulakis, Charalabos, Iliopoulos, Dimitrios, Gregory, Richard I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227872/
https://ncbi.nlm.nih.gov/pubmed/22118463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.039
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