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Inhibition of XPO1 enhances cell death induced by ABT‐199 in acute myeloid leukaemia via Mcl‐1

The antiapoptotic Bcl‐2 family proteins play critical roles in resistance to chemotherapy in acute myeloid leukaemia (AML). The Bcl‐2‐selective inhibitor ABT‐199 (Venetoclax) shows promising antileukaemic activity against AML, though Mcl‐1 limits its antileukaemic activity. XPO1 is a nuclear exporte...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Luedtke, Daniel A., Su, Yongwei, Liu, Shuang, Edwards, Holly, Wang, Yue, Lin, Hai, Taub, Jeffrey W., Ge, Yubin
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237582/
https://ncbi.nlm.nih.gov/pubmed/30596398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13886
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